05 Jul , 22:16
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NEUROLOGICAL SENSATION: PARKINSON'S DISEASE MAY ORIGINATE IN THE KIDNEYS, NOT THE BRAIN
Until now, certain areas of the brain, particularly the substantia nigra where dopamine neurons are destroyed, were considered the main focus of the disease development. It is precisely the dopamine deficiency that leads to characteristic symptoms: tremor, muscle rigidity, and impaired movement coordination. However, fresh data suggest that the trigger for the disease may occur much earlier and in a completely different organ.
Researchers have discovered striking abnormalities in kidney function in patients with early-stage Parkinson's. Observations revealed molecular signals and protein deposits identical to those typically found in the brains of patients. What is especially important is that a significant proportion of patients showed inflammatory markers and clear signs of oxidative stress in kidney tissue several years before any neurological symptoms appeared.
Scientists are proposing a revolutionary hypothesis: the pathological protein alpha-synuclein, a key player in Parkinson's disease, may initially accumulate in the kidneys and trigger a chain reaction that gradually reaches the brain through the nervous system. This discovery opens up incredible prospects for early diagnosis and prevention of the disease.
If the hypothesis is confirmed in further studies, the approach to treating Parkinson's could change dramatically. Instead of fighting the consequences of brain destruction, doctors will be able to target the original source of the disease - even before motor symptoms appear.
This discovery also emphasizes the importance of a systemic approach to health: organs in the human body are closely connected, and a disease manifesting in one may actually begin in another.