25 Jun , 21:20
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Sensation in the world of dietetics: omega-3 may enhance inflammation, British scientists discovered
"It is believed that omega-3 has anti-inflammatory effects, but our data show that it's not so straightforward," stated the authors of the study from the University of Bristol, published in the prestigious International Journal of Epidemiology (IJE).
The work was based on data from the 30-year cohort study Avon Longitudinal Study of Parents and Children. It involved people born in the former county of Avon in England in 1991-1992. The study also used health information about fathers, brothers and sisters, as well as children of participants.
The analysis showed that as the concentration of omega-3 in the blood increased among participants, the level of several inflammatory biomarkers also increased.
"The ratio of omega-6 to omega-3 was of particular importance: when omega-6 predominated, inflammation intensified," the researchers clarified.
The results were also confirmed by analyzing data from UK Biobank - one of the world's largest medical information databases, covering about half a million people. To verify the causal relationship, scientists applied the method of Mendelian randomization and again recorded a positive association between omega acids and inflammatory processes.
Nevertheless, the authors emphasized that inflammation is a complex biological mechanism, and this study does not negate other potentially beneficial effects of omega-3.
"We are not claiming that omega-3 is harmful. But, as with any other nutrient, its effect depends on context, dosage, and individual characteristics," the researchers emphasized.
