# Brain Signal Discovered That Causes the Body to Burn Fat

# Scientists Reveal the Secret of "Stubborn" Fat: Brain Signal Can Melt Even the Most Resistant Deposits **A revolutionary discovery by American researchers is overturning ideas about fighting excess weight: it turns out that a specific hormonal signal from the brain can trigger fat burning in the most hard-to-reach areas of the body — and without any diets or exhausting workouts.** As reported by **TUT.AZ**, the groundbreaking work by scientists from Washington University School of Medicine was published in the prestigious journal Nature Metabolism. The focus of attention was the hormone leptin and its remarkable ability to "reach" fat cells that were previously considered virtually impenetrable. We're talking about the mysterious inhabitants of our bones — the so-called constitutive bone marrow adipocytes. Few people know this, but in adults, nearly 70% of bone marrow consists of fatty tissue. And most interestingly — it stubbornly ignores any attempts to lose weight: neither strict diets nor marathon runs have any effect on these reserves. It's all due to special protective proteins that reliably block fat breakdown. However, laboratory experiments on mice delivered a real surprise. When scientists began injecting leptin directly into the animals' brains, something astonishing happened: glucose and insulin levels dropped, protective proteins retreated, and fat reserves virtually disappeared within just a few days. And all this — with the exact same diet! That said, researchers urge caution before jumping to conclusions. The discovered mechanism possesses enormous power, which means it requires extreme care. Similar "untouchable" fat depots are located not only in bones — they surround vital glands and are found in the areas of hands and feet. In severely ill patients, uncontrolled loss of this tissue threatens increased bone fragility and serious health deterioration. According to the study authors, the decoded mechanism opens two promising directions in medicine at once. On one hand — the possibility of protecting fatty tissue in people suffering from cachexia (catastrophic wasting in chronic diseases). On the other — controlled influence on stubborn fat deposits could become a new breakthrough in obesity treatment.