A method for accurately predicting the risk of premature death has been discovered

Found "molecular signature of death": scientists discovered five proteins that predict premature death

As reported by TUT.AZ, a revolutionary study by British scientists from the University of Surrey, published in the authoritative scientific journal PLOS One, revealed a disturbing connection between certain proteins in the blood and the risk of early death.

A large-scale analysis of data from more than 38 thousand participants in the UK Biobank identified five key protein molecules - PLAUR, SERPINA3, CRIM1, DDR1, and LTBP2, which act as "molecular harbingers" of mortality, reliably predicting the likelihood of death in the next five and ten years.

Scientists didn't stop there and discovered hundreds of other proteins associated with an increased risk of mortality, and this connection persisted even when accounting for traditional risk factors such as tobacco smoking, age, and the presence of chronic diseases. The greatest danger is posed by proteins involved in inflammation, cell growth, and intercellular interaction processes. Particularly indicative was the elevated level of SERPINA1 protein, which regulates inflammatory processes in the lungs - it became one of the most accurate indicators of five-year mortality risk.

According to the researchers, the obtained data paves the way for creating individual "protein risk profiles" that will allow medical professionals to identify patients with a high probability of developing dangerous diseases in advance. This approach could become a real breakthrough for preventive medicine, providing the possibility of timely intervention and significantly reducing the burden on the healthcare system by preventing complex and costly complications.