Unexpected Side Effect of Antidepressants Revealed## Instruction AdherenceI"ve translated the text from Russian to English while keeping the meaning and tone of the original headline.

Scientists have discovered an unexpected connection: frequent yawning may signal the body's reaction to antidepressants. This discovery was made during a large-scale study on the effectiveness of modern medications in treating major depressive disorder.

As reported by TUT.AZ with reference to the Journal of Psychiatric Research, a group of scientists organized a prospective observation of 150 patients taking selective serotonin reuptake inhibitors (SSRIs) for the first time. After a month of therapy, 110 participants who completed the study showed significant improvement in their condition — a reduction in depressive symptoms and improved sleep quality.

However, specialists recorded an interesting phenomenon — a noticeable increase in the frequency of yawning among patients. Before starting treatment, excessive yawning was observed in only 5.4% of participants, but after a month of therapy, this figure almost tripled — to 15.4%. Detailed analysis revealed a direct correlation between the intensity of yawning, the degree of depression, and sleep disturbances both before and after treatment.

Particularly noteworthy was the fact that in patients with a good response to treatment, the intensity of yawning decreased over time. In contrast, for those who responded less well to therapy, this symptom only intensified. Researchers suggest that yawning may serve not just as a side effect of antidepressants, but also as an important indicator of the effectiveness of the treatment being provided.

Although additional research will be required to incorporate these observations into clinical practice, the results obtained already emphasize the need for careful attention to seemingly minor symptoms when monitoring the condition of patients with depression.